CCR8
OVERVIEW
Chemokine C-C motif receptor 8 (CCR8) is a chemokine receptor .1 expressed on regulatory T cells (Tregs) that interacts with the chemokine CCL1.1 CCR8 has been previously associated with chemotaxis, cell/cell interactions in the context of T-helper type 2 cell responses, and T-cell trafficking to the skin.1-2
IMPLICATIONS IN CANCER
Within tumors, Tregs are a key immunosuppressive cell population known to prevent antitumor immune responses; high intratumoral Treg levels have been associated with negative outcomes in several cancers.3-5 CCR8 is more highly expressed on Tregs found in the tumor microenvironment(TME) and is upregulated in tumor tissues, including head and neck squamous cell carcinoma (HNSCC), non-small cell lung cancer (NSCLC), and colorectal cancer (CRC).6-7 CCR8 is highly expressed in tumor-infiltrating Tregs and correlates with poor prognosis in both NSCLC and CRC patients.6
Related Research
- Chensue SW, Lukacs NW, Yang TY, et al. Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice. J Exp Med. 2001;193:573-584.
- Schaerli P, Ebert L, Willimann K, et al. A skin-selective homing mechanism for human immune surveillance T cells. J Exp Med. 2004;199:1265-1275.
- Shang B, Liu Y, Jiang SJ, et al. Prognostic value of tumor-infiltrating FoxP3+ regulatory T cells in cancers: a systematic review and meta-analysis. Sci Rep. 2015;5:15179.
- Fridman WH, Zitvogel L, Sautes-Fridman C, et al. The immune contexture in cancer prognosis and treatment. Nat Rev Clin Oncol. 2017;14(12):717-34.
- Bruni D, Angell HK, Galon J. The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy. Nat Rev Cancer. 2020;20(11):662-80.
- Meng L, et al. CCR4, CCR8, and P2RY14 as prognostic factors in head and neck squamous cell carcinoma are involved in the remodeling of the tumor microenvironment. Front Oncol. 2021;11:618187.
- De Simone M, et al. Transcriptional landscape of human tissue lymphocytes unveils uniqueness of tumor-infiltrating t regulatory cells. Immunity. 2016;45:1135-1147.
