Seizure-related homolog 6 (SEZ6) is a transmembrane protein found on the cell surface of select neuronal lineage cells.1,2


SEZ6 is selectively expressed on neuroendocrine tumors, including small cell lung cancer (SCLC).3 Accordingly, SEZ6 is a potential target for the development of novel antibody drug conjugates (ADC) carrying payloads designed to kill neuroendocrine tumor cells, thereby treating patients with such tumors.

  • Using a bioinformatic approach, RNA expression analysis and immunohistochemistry identified SEZ6 as a highly expressed surface marker in neuroendocrine tumors including SCLC, with limited expression in normal tissue.
  1. Shimizu-Nishikawa K, et al. Cloning and characterization of seizure-related gene, SEZ-6. Biochem Biophys Res Commun. 1995;216(1):382-9.
  2. Gunnersen JM, et al. Sez-6 proteins affect dendritic arborization patterns and excitability of cortical pyramidal neurons. Neuron. 2007;56(4):621-39.
  3. Kudoh S, et al. Significance of achaete-scute complex homologue 1 (ASCL1) in pulmonary neuroendocrine carcinomas; RNA sequence analyses using small cell lung cancer cells and Ascl1-induced pulmonary neuroendocrine carcinoma cells. Histochem Cell Biol. 2020;153(6):443-456.