BLASTIC PLASMACYTOID DENDRITIC CELL NEOPLASM (BPDCN)

<1%

of all hematologic malignancies in the US.1,2

3x

as many males are impacted
as females1

18 months

median overall survival from diagnosis3

  • Estimated cases of BPDCN per 100,000 in the US population: 0.045
  • Median age at diagnosis: mid 60s4,6-7
  • Percent of cases that present with cutaneous manifestations: Approximately 90%6

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, aggressive hematologic malignancy derived from plasmacytoid dendritic cell precursors with skin, lymph node, blood, central nervous system (CNS), and bone marrow involvement.8 While BPDCN is currently considered a unique myeloid neoplasm, it had previously been classified as a subset of acute myeloid lymphoma (AML).9

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, aggressive hematologic malignancy derived from plasmacytoid dendritic cell precursors with skin, lymph node, blood, central nervous system (CNS), and bone marrow involvement.8 While BPDCN is currently considered a unique myeloid neoplasm, it had previously been classified as a subset of acute myeloid lymphoma (AML).9

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, aggressive hematologic malignancy derived from plasmacytoid dendritic cell precursors with skin, lymph node, blood, central nervous system (CNS), and bone marrow involvement.8 While BPDCN is currently considered a unique myeloid neoplasm, it had previously been classified as a subset of acute myeloid lymphoma (AML).9

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, aggressive hematologic malignancy derived from plasmacytoid dendritic cell precursors with skin, lymph node, blood, central nervous system (CNS), and bone marrow involvement.8 While BPDCN is currently considered a unique myeloid neoplasm, it had previously been classified as a subset of acute myeloid lymphoma (AML).9

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, aggressive hematologic malignancy derived from plasmacytoid dendritic cell precursors with skin, lymph node, blood, central nervous system (CNS), and bone marrow involvement.8 While BPDCN is currently considered a unique myeloid neoplasm, it had previously been classified as a subset of acute myeloid lymphoma (AML).9

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  2. Bueno C, et al. Haematologica. 2004;89(1):58-69.
  3. Laribi K, et al. Blood Adv. 2020;4(19):4838-4848. 
  4. Sullivan JM, Rizzieri DA. Hematology Am Soc Hematol Educ Program. 2016;2016(1):16-23.
  5. Murthy GSG, et al. Leuk Res. 2018;73:21-23.
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  20. Han L, et al. Cytometry A 2015;87:346-56.
  21. Pemmaraju N, Deconinck E, Mehta P, et al: Recent advances in the biology and CD123-directed treatment of blastic plasmacytoid dendritic cell neoplasm. Clin Lymphoma Myeloma Leuk 24:e130-e137, 2024.