MALT1 drives NF-κb expression in many cancers leading to enhanced cell survival and proliferation.3 MALT1 regulates NF-κb, but unlike NF-κb, is not essential for survival.
MALT1 plays a role in B-cell malignancies. 4,5
- MALT1 is involved B-cell lymphocyte activation.
- Specific B cell malignancies, including the aggressive non-germinal center B cell-like (GCB) subtype of diffuse large B cell lymphoma (DLBCL) and chronic lymphocytic leukemia (CLL), are driven by constitutive activation of NF-κB.