Chemokine C-C motif receptor 8 (CCR8) is a member of the beta chemokine receptor family.1 CCR8 is expressed on T regulatory cells (Tregs) and interacts with the chemokine CCL1. CCR8 plays a role in regulation of monocyte chemotaxis, thymic cell apoptosis, and T cell migration.2


Tregs chemotaxis through CCL1‐CCR8 into the tumor microenvironment (TME).2 Tregs suppress the immune response, promote cancer progression, and promote resistance to checkpoint inhibitors.3 CCR8 is overexpressed in Tregs found in the TME and is upregulated in tumor tissues, including head and neck squamous cell carcinoma (HNSCC), non-small cell lung cancer (NSCLC), and colorectal cancer (CRC).3,4 CCR8 is highly expressed in tumor-infiltrating Tregs and correlates with poor prognosis in both NSCLC and CRC patients.4 Targeting CCR8 in a mouse model of lung cancer reduced tumor burden, demonstrating a potential role for CCR8+ Tregs in immunosuppression of lung cancer.5

  1. Liu L, et al. Biological characterization of ligands targeting the human CC chemokine receptor 8 (CCR8) reveals the biased signaling properties of small molecule agonists. Biochem Pharmacol. 2021;188: 114565.
  2. Ohue Y and Nishikawa H. Regulatory T (Treg) cells in cancer: Can Treg cells be a new therapeutic target? Cancer Sci. 2019; 110(7):2080-2089.
  3. Meng L, et al. CCR4, CCR8, and P2RY14 as Prognostic Factors in Head and Neck Squamous Cell Carcinoma Are Involved in the Remodeling of the Tumor Microenvironment. Front Oncol. 2021; 11: 618187.
  4. De Simone M, et al. Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells. Immunity. 2016;45:1135-1147.
  5. Haruna M, et al. The impact of CCR8+ regulatory T cells on cytotoxic T cell function in human lung cancer. Sci Rep. 2022;12: 5377.